THC-O vs THC-P in additional element

THC-O is brief for THC-O-acetate. THC-O is an acetate ester of THC. It exerts affect on our physique’s endocannabinoid system however is not discovered naturally in hemp or hashish vegetation, thereby classifying it as an artificial cannabinoid.

Some folks argue that THC-O is a semi-synthetic cannabinoid as a result of it’s created from pure cannabinoids.

THC-O is created by a means of acetylation, utilizing Delta 8 or Delta 9 THC as a place to begin, by which an further acetate group of atoms is created within the chemical construction. This makes it a pro-drug, that means it needs to be metabolized earlier than it turns into energetic.

In the course of the metabolic course of the acetate group disperses permitting the THC to bind to receptors of their regular trend. It’s thought that the variations in psychoactive results and efficiency (to THC) are attributable to this pro-drug supply technique which affords it greater bioavailability.

THC-P is brief for tetrahydrocannabiphorol. It’s certainly one of over 140 (and counting) naturally-occurring phytocannabinoids which were recognized and remoted from hemp and hashish vegetation. Nonetheless, THC-P was solely recognized and remoted very lately (in 2019), so scientific analysis into this minor cannabinoid is scarce.

THC-P is a minor cannabinoid, solely occurring within the plant in very small quantities. This makes it extremely possible that THC-P merchandise include a semi-synthetic model of this compound created from Delta 8 or Delta 9 THC.

In the event you have a look at the molecular construction of THC-P, it’s just like Delta 9 THC, however encompasses a longer seven-carbon sidechain in comparison with Delta 9 THC’s five-carbon sidechain. This longer sidechain affords THC-P a 33-fold higher binding affinity for the cannabinoid receptors in our mind, that means it additionally has a higher potential to intoxicate us.

Is THC-P stronger than THC-O?

**The ultimate efficiency of THC-O or THC-P largely will depend on which type of THC was used to create it.**

If we’re to have a look at the advertising and marketing hype surrounding THC-P vs O, THC-O is alleged to be thrice stronger that Delta 9 THC and THC-P is alleged to be round 33 instances stronger.

However, in precise truth, this simply isn’t true. Sorry, I do know you’re most likely in search of a straight reply right here, however there isn’t one!

Many customers have reported that THC-O feels round two to a few instances stronger than common THC however, in my expertise, the excessive could be very completely different which makes it harder to quantify. For instance, I’ve taken 25 mg THC-O gummies previously and have nonetheless been in a position to perform in ways in which simply wouldn’t be potential for me on 25 mg of Delta 9 THC (extra on this within the results, later).

The marketed efficiency of THC-P is simply that, advertising and marketing. Though analysis has discovered that THC-P is ready to bind 33X extra effectively with CB1 receptors in our mind, this analysis was carried out in petri dishes and the analysis staff discovered very completely different outcomes when it got here to testing this compound in vivo (in life).

This analysis did conclude that THC-P is stronger than THC, simply not 33X stronger. The staff discovered that THC-P was in a position to exert THC-like results in mice at round half the dose of standard (Delta 9) THC.

Nonetheless, the efficiency of THC-P remains to be hotly debated, with many skilled customers claiming it to be round 5-10 instances as robust as THC.

The issue is, expertise and anecdotal proof will not be notably useful as a result of there aren’t any THC-P (solely) merchandise in the marketplace in the meanwhile. In the event you purchase a vape cart or gummy with THC-P in it, it’s all the time accompanied by a lot bigger quantities of CBD, Delta 8 THC, or different cannabinoids, so it’s virtually unimaginable to inform what’s doing what.

On prime of this, I’ve seen carts labeled as 100% THC-P that solely include round 2% THC-P, so you really want to buy round earlier than choosing a product that may truly provide respectable THC-P results.

In my private expertise, I’d say that THC-P elicits stronger results than THC-O relating to THC-like results. Nonetheless, THC-O is ready to present extra psychedelic results, particularly at greater doses.

What’s the strongest THC variant?

As a seven-carbon chain THC, THC-P is the strongest THC variant that has formally been recognized and remoted. Nonetheless, THCjd is an eight-carbon chain THC, which (theoretically-speaking) would probably make THCjd a stronger variant.

THCjd has been showing in varied merchandise for some time now, however scientific proof supporting its official existence is missing.

It’s value mentioning that THC efficiency alone doesn’t essentially dictate the general high quality or results of a hashish pressure or product. The presence of different cannabinoids and compounds (akin to CBD and varied terpenes) can even affect the general expertise and therapeutic potential.

THC-P vs THC-O results

You’ll be able to learn extra concerning the results of THC-P and the results of THC-O on the hyperlinks.

However, briefly, the THC-O expertise is extra lucid and non secular than some other THC expertise I’ve had. The consequences take longer to kick in and it could possibly nonetheless take some time to comprehend that you simply’re excessive as a result of it doesn’t include the standard feeling of intoxication attributable to most different THC variants.

In truth, it’s nicknamed the “non secular cannabinoid” because of its distinctive results.

The consequences of THC-P are much more just like Delta 9 THC, only a lot stronger. THC-P has extra euphoric results, in addition to a extra noticeable physique buzz than THC-O. You’ll additionally discover the consequences extra instantly, not simply because it really works quicker, but additionally since you really feel bodily intoxicated.

Though the consequences of all types of THC may be described as psychedelic (you gained’t hallucinate however you could expertise a sense of expanded consciousness), THC-O positively takes this to the following stage.

Which is safer: THC-P or THC-O?

In all honesty, each of those cannabinoids are missing the scientific analysis wanted to precisely touch upon their security. Nonetheless, since THC-P is a pure cannabinoid, it could be assumed to have an analogous security profile to Delta 9 THC, with solely delicate and rare negative effects.

As an acetate ester, there’s much more concern surrounding the protection of THC-O, relating to vaping merchandise specifically.

You could have heard of the hazards of vaping vitamin-E-acetate and, in that case, the identical risks exist for THC-O-acetate. Though acetates recurrently seem in merchandise which can be deemed suitable for eating, the issue comes when acetate is heated (which, after all, it is going to be when it’s vaped or smoked). 

Proof means that heating THC-O might outcome within the manufacturing of ketene, a suspected reason for extreme lung damage.

For that reason, in case you’re inquisitive about making an attempt THC-O, it could be smart to go for edibles over inhalables.

THC-P vs THC-O legality

One other vital distinction between THC-P and THC-O is their legality. As a naturally-occurring cannabinoid, THC-P falls underneath the definition of hemp and is authorized on the federal stage in accordance with the Hemp Farming Act of 2018.

THC-O, however, can’t be discovered naturally within the hemp plant. As a totally artificial cannabinoid, the DEA launched an announcement in February 2023 stating that, as a result of THC-O can’t be present in hemp, it doesn’t fall underneath the definition of hemp. On this assertion, the DEA declared THC-O to be a schedule I substance.

A number of corporations are nonetheless promoting THC-O merchandise, so (for now at the very least) it seems that this isn’t being enforced, however you need to be conscious of this in case you’re planning on shopping for some and making an attempt it for your self.